Arthur M. Silverstein directed a recent paper at those “challenging” the clonal selection theory (CST) because of its obsolete notions of. The clonal selection theory of antibody formation is the most important advance in immunology in the past hundred years. Previous models of antibody formation. Jump to Burnet's clonal selection theory - Clonal selection theory is a scientific theory in immunology that explains the functions of cells (lymphocytes) of the immune system in response to specific antigens invading the body. In short the theory is an explanation of the mechanism for the generation of diversity of antibody specificity.‎Early work · ‎Further work · ‎Theories supported by.


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Conclusion The proper evaluation of the roles of the major protagonists in the conception and development of the clonal selection theory is an ongoing task for professional historians of clonal selection theory With his background in virology and immunology, Burnet was ideally prepared for the clonal selection approach.


It is possible that the verdict of history will be that he spread himself too widely in his scientific interests. In he was clonal selection theory engaged in the cancer problem 5.

Sir Frank Macfarlane Burnet and the clonal selection theory of antibody formation.

Talmage seems to have been more focused. Yet those very qualities that denied Burnet clonal selection theory in conceiving the clonal selection theory appear to have uniquely qualified him for the subsequent task of exploring its implications.

Does it really matter who originated the clonal selection concept in immunology? Every day thousands of decisions are made by peers.

Reflections on the clonal-selection theory.

As authors, peers decide whose papers will be cited and whose will not. As reviewers, they decide clonal selection theory papers will be published and whose will not, and whose research projects will be funded and whose will not.

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It would seem of vital importance for the healthy development of science that peers get these decisions right. Getting it right with clonal selection theory to the few, highly visible issues should serve as a guide to getting it right with regard to the multiplicity of less visible issues.

The error-proneness of evaluation in science demonstrated here has important implications for the design of evaluation systems, as discussed elsewhere 10, Summary Evaluation of high achievement forms part of an evaluation continuum operating throughout the scientific enterprise.

Correct evaluation of individuals and their work means that the best clonal selection theory is published and the most able individuals obtain research grants and awards.

Reflections on the clonal-selection theory.

It is important that evaluations be carried out fairly and objectively. This paper considers clonal selection theory of the roles of Ehrlich, Jerne, Talmage, and Burnet in the conception and development of the clonal selection theory, which revolutionized our understanding of body defences against foreign organisms.

These evaluations show varying degrees of bias; in particular, the major role of Ehrlich tends to be overlooked. Contradicting the conventional clonal selection theory, the objective record shows that Talmage, not Burnet, first conceived clonal selection.

Clonal selection theory

The error-proneness of evaluation in science suggests that our evaluation processes should be redesigned to take this into account. Note added in proof clonal selection theory the published paper: Further information on Jerne's role is provided by an article entitled "Darwinian overtones: Jerne and the origin of the selection theory of antibody formation" by Thomas SoderqvistJ Hist Biol 27, Australian Journal of Science 20, Cambridge University Press, Cambridge.

Essays on the History of Immunology.

Edited by Mazumdar, P. The Life of Sir Macfarlane Burnet. Oxford University Press, Melbourne, Australia.

Academic Press, San Diego.

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